本文探討四氧化三鐵（Fe3O4）磁性奈米粒子之製備、特性研究及其在生醫腫瘤熱治
療之應用。內容主要分為以下三個部份，包含現階段奈米生物醫學之現況與發展、磁性
奈米粒子之製備及其特性之研究、腫瘤熱治療之理論與應用。磁性奈米粒子具有超順磁
性、高飽和磁化量及高有效表面積等特性，製備過程使用葡聚醣等界面活性劑修飾其團
聚特性及生物相容性及毒性等相關問題。磁性奈米粒子目前已被廣泛的運用在生物醫學
的研究領域上，如腫瘤治療、靶向藥劑、基因篩選或細胞分離、核磁影像檢測等。結合
磁性奈米粒子之熱治療，藉由外部交流磁場加熱磁性奈米粒子促使腫瘤組織溫度提高超
過43℃以上，破壞腫瘤之新生血管，有效抑制其營養供給，來達到治療腫瘤之成效，並
且無侵襲性之問題，可作為化學治療與放射治療之輔助療法。本文亦探討及評估四氧化
三鐵磁性奈米粒子對於腫瘤熱治療各項物理、化學或生物等影響因素，包含超順磁性、
親水性、粒徑分佈、熱產率、穩定性、表面電荷、pH 值影響因素等。

關鍵字：磁性奈米粒子、超順磁性、界面活性劑、葡聚醣、熱治療

Nano-particles and Its Applications in Hyperthermia

1Hong-Yi Chen 1Kwo-Ping Chang 1*Chang-Shu Tsai

1* Institute of Radiological Science, Tzu-Chi College of Technology

Abstract

Magnetic nano-particles are extensively studied in tumor therapy, target drug, gene
screen, cell separation and magnetic resonance imaging study, due to theirs unique features
such as its superparamagnetism, high saturation magnetization and high effective surface
areas, etc. The aims of this work is to emphasize on the preparation and characterization of
Fe3O4 magnetic nano-particles and its applications in the field of hyperthermia . Hyperthermia
is adjuvant treatment for chemical and radiation therapy. Besides, there is no invasion
problems that the treatments may increase tumor temperature about 43 ℃ or more by external
alternating magnetic field to heat the nanoparticles, and destroy tumor angiogenesis,
effectively inhibited its nutritional supply, which achieve the effective treatment to the cancer.
In this study, the dextran as a surfactant is used to modify the nanoparticle surface. In
addition, the properties of variety of physical and chemical properties including
superparamagnetism, hydrophilic, particle size, SAR value, stability, surface potential, pH
value influence , are performed and discussed.

Keywords：Fe3O4 magnetic nanoparticles, superparamagnetism, surfactant, dextran,
hyperthermia,